A slice of the nervous system (LTP and LTD)
Long-term potentiation (LTP)
Properties of LTP
Induced by brief stimulation, input specificity, cooperativity, associability
Long-term depression (LTD)
Low freq. stim.-->LTD, high freq. stim-->LTP
May prevent saturation
Long-term mechanisms yield structural modifications
Pharmacological studies
Antagonists: APV (AP5) and MK-801
Affect induction, not expression
Impact on spatial learning
Impact on fear conditioning (Fanselow)
