Lesion: electrolytic & neurochemical (spares fibers of passage)

Inference of function through dysfunction

Activation: electrical and neurochemical

Mimicry/substitution

Record activity (cellular and regional)

Advantages of the eyeblink paradigm

Brainstem and cerebellum

Necessary and sufficient for delayed conditioning

Neural systems

US pathway (from trigeminal n.)

Reflex pathways (reticular formation and cranial motor n.)

Teaching pathway (inferior olive, interpositus n., climbing fibers, and cerebellar cortex)

CS pathway (from auditory n.)

From pontine n. to interpositus n. and cerebellar cortex (via mossy fibers)

Convergence

Mossy fibers to parallel fibers w/radiating projections

Climbing fibers interact with Purkinje cells

Determines CS-R pathway strengthened

Inhibition of inferior olive and blocking

Anatomy

Components of the limbic system

Organization

Role in fear (Fanselow, LeDoux)

US pathways

CS pathways

Convergence within the basolateral amygdala

Memory consolidation (McGaugh)

Appetitive conditioning and attention (Holland and Gallagher)

Impact of anterior basolateral lesions on second-order conditioning

Impact of central nucleus lesions on increments in associability